Preheat oven to 400 degrees. In a bowl, combine beef, egg, diced onion, breadcrumbs, 2 tablespoons ketchup, Worcestershire sauce, 1/4 teaspoon garlic powder, 1/4 teaspoon salt and 1/4 teaspoon pepper. Blend together and then form into a loaf pan. Brush the tops with ketchup. Place meat loaves onto the bottom rack of hot oven.